Hyperhomocysteinemia and MTHFR gene 677 C>T polymorphism: questionable role in female infertility
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چکیده
منابع مشابه
Hyperhomocysteinemia and MTHFR gene 677 C>T polymorphism: questionable role in female infertility
Background: Homocysteine is an intermediate in methionine metabolism required for the biosynthesis of nucleic acids. Hyperhomocysteinemia affects various organ systems and also has been implicated as a risk factor for infertility. Elevated levels result either from genetic mutations of the enzymes catalyzing the metabolic pathway or deficiency of micronutrients required as co-enzymes for the sa...
متن کاملHyperhomocysteinemia, MTHFR 677C3T Polymorphism, and Stroke
Hyperhomocysteinemia, MTHFR 677C3T Polymorphism, and Stroke To the Editor: We welcome the report from Madonna and co-workers examining the role of prothrombotic and homocysteine (Hcy) pathway polymorphisms in risk of ischemic stroke in young adults.1 We wish to comment on several issues raised by their article relating to the design of studies of genetic risk factors for complex phenotypes such...
متن کاملHyperhomocysteinemia, MTHFR 677C-->T polymorphism, and stroke.
Hyperhomocysteinemia, MTHFR 677C3T Polymorphism, and Stroke To the Editor: We welcome the report from Madonna and co-workers examining the role of prothrombotic and homocysteine (Hcy) pathway polymorphisms in risk of ischemic stroke in young adults.1 We wish to comment on several issues raised by their article relating to the design of studies of genetic risk factors for complex phenotypes such...
متن کاملMTHFR rs1801133 Gene Polymorphism and Autism Susceptibility
Background: It is believed that environmental and genetic factors may be responsible for autism. Methylenetetrahydrofolate reductase (MTHFR) and its gene polymorphisms have been shown to be implicated as risk factors in autism. Objectives: To analyze MTHFR C677T polymorphism (rs1801133) in autistic patients. Materials and Methods: This study was carried out in 2014 and 2015 in northern Ir...
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Many studies have shown that hyperhomocysteinemia may be an independent risk factor for thromboembolic disease. However, the results among studies and populations have not been consistent. Furthermore, the possible mechanisms of hyperhomocysteinemia in vascular diseases are controversial. Mutations in the MTHFR (5,10-methylenetetrahydrofolate reductase) gene, resulting in rising levels of plasm...
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ژورنال
عنوان ژورنال: International Journal of Reproduction, Contraception, Obstetrics and Gynecology
سال: 2015
ISSN: 2320-1770
DOI: 10.18203/2320-1770.ijrcog20150074